Slater G, Papatestas A E, Genkins G, Kornfeld P, Horowitz S H
Surg Gynecol Obstet. 1978 Jan;146(1):54-6.
Until recently, thymectomy has been reserved for patients with myasthenia gravis in the younger age groups. The use of transcervical thymectomy, with its reduction in morbidity and mortality, has allowed us to study the effects of thymectomy in the older age group. The records of 525 patients who underwent thymectomy were reviewed and divided into two groups: those less than and those more than 40 years of age. The incidence of thymomas was greatest in the older than 40 year group. This age group without thymoma was also noted to have a high incidence of absent germinal centers. The postoperative remission rates as well as the electromyographic improvement rates were comparable for both age groups. The evidence presented indicates that thymectomy improves the clinical course of myasthenia gravis in all age groups studied. We recommend transcervical thymectomy for all patients with generalized myasthenia gravis, regardless of age.
直到最近，胸腺切除术一直仅用于较年轻年龄段的重症肌无力患者。经颈部胸腺切除术的应用，因其降低了发病率和死亡率，使我们能够研究胸腺切除术对老年组患者的影响。我们回顾了525例行胸腺切除术患者的记录，并将其分为两组：年龄小于40岁和大于40岁的患者。胸腺瘤的发生率在40岁以上组最高。还注意到该年龄组无胸腺瘤者生发中心缺失的发生率也很高。两个年龄组的术后缓解率以及肌电图改善率相当。所提供的证据表明，胸腺切除术改善了所有研究年龄组重症肌无力的临床病程。我们建议对所有全身型重症肌无力患者，无论年龄大小，均行经颈部胸腺切除术。
