Laboratory of Health and Environment, Department of Biology, Faculty of Sciences Ain Chock, University of Hassan II, Casablanca, Morocco.
Laboratory of Health and Environment, Department of Biology, Faculty of Sciences Ain Chock, University of Hassan II, Casablanca, Morocco.
Curr Res Transl Med. 2019 May;67(2):62-71. doi: 10.1016/j.retram.2019.01.005. Epub 2019 Jan 23.
Diabetic retinopathy (DR) and retinopathy of prematurity (ROP) present two examples of proliferative retinopathy, characterized by the same stages of progression; ischemia of the retinal vessels, leads to hypoxia and to correct the problem there is the setting up of uncontrolled angiogenesis, which subsequently causes blindness or even detachment of the retina. The difference is the following; that DR initiated by the metabolic complications that are due to hyperglycemia, and ROP is induced by overexposure of the neonatal retina to oxygen. In this review, we will demonstrate the physiopathological mechanism of the two forms of proliferative retinopathy DR and ROP, in particular the role of the CD40/CD40L axis and IL-1 on vascular complications and onset of inflammation of the retina, the implications of their effects on the onset of pathogenic angiogenesis, thus understanding the link between platelets and retinal ischemia. In addition, what are the therapeutic targets that could slow its progression?
糖尿病性视网膜病变 (DR) 和早产儿视网膜病变 (ROP) 是增殖性视网膜病变的两个例子，其特征是具有相同的进展阶段；视网膜血管缺血，导致缺氧，为了解决这个问题，出现了不受控制的血管生成，随后导致失明甚至视网膜脱离。区别如下：DR 是由高血糖引起的代谢并发症引起的，ROP 是由新生儿视网膜过度暴露于氧气引起的。在这篇综述中，我们将展示 DR 和 ROP 两种形式的增殖性视网膜病变的病理生理机制，特别是 CD40/CD40L 轴和 IL-1 在血管并发症和视网膜炎症发病中的作用，它们对病理性血管生成发病的影响，从而理解血小板与视网膜缺血之间的联系。此外，有哪些治疗靶点可以减缓其进展？
