Kennedy P G
J Neuroimmunol. 1982 Jan;2(1):35-53. doi: 10.1016/0165-5728(82)90074-1.
Cell-type-specific antigenic markers which allow the unambiguous identification of the major neural cell types in dissociated cell cultures of central nervous system (CNS) and peripheral nervous system (PNS) tissues from a variety of animal species have recently been established. The use of many of these markers has also been extended to nervous tissue sections in which the in vivo properties of neural cells can be studied. Markers may be either cell surface or intracellular components of neural cells. Cell surface markers can be used to separate different cell types to produce purified cell populations. The ability of monoclonal antibodies to recognise single antigenic determinants is likely to prove superior to conventional heteroantisera in recognising cell surface antigens. Although the present techniques have intrinsic limitations, nonetheless both surface and intracellular markers should prove to be of great value in a wide range of biological and clinical neurological studies.
最近已经建立了细胞类型特异性抗原标志物，这些标志物能够明确鉴定来自多种动物物种的中枢神经系统（CNS）和外周神经系统（PNS）组织的解离细胞培养物中的主要神经细胞类型。其中许多标志物的应用也已扩展到神经组织切片，在这些切片中可以研究神经细胞的体内特性。标志物可以是神经细胞的细胞表面成分或细胞内成分。细胞表面标志物可用于分离不同的细胞类型以产生纯化的细胞群体。单克隆抗体识别单一抗原决定簇的能力在识别细胞表面抗原方面可能优于传统的异种抗血清。尽管目前的技术存在固有局限性，但表面和细胞内标志物在广泛的生物学和临床神经学研究中都应具有很大的价值。
