Ryberg B
J Neuroimmunol. 1983 Feb;4(1):9-15. doi: 10.1016/0165-5728(83)90059-0.
The complement-fixing antibrain antibodies which may be found in patients with multiple sclerosis (MS) belong to several specificities, of which only two are as yet identified. In order to study three of the incompletely characterized specificities, the ontogenetic evolution of the corresponding antigens in mouse brain was followed. MS serum containing antibodies to sulfatide, a relatively myelin-specific glycolipid, served as a control. The studied antigens were virtually absent at birth and accumulated at different rates during the postnatal period. The results give valuable clues for the further study of the antibrain antibodies in MS.
多发性硬化症（MS）患者体内可能存在的补体结合抗脑抗体具有多种特异性，其中只有两种已被鉴定出来。为了研究三种特征尚未完全明确的特异性，对小鼠脑中相应抗原的个体发生演变进行了追踪。含有抗硫脂抗体的MS血清用作对照，硫脂是一种相对髓鞘特异性的糖脂。所研究的抗原在出生时几乎不存在，并在出生后的时期以不同的速率积累。这些结果为进一步研究MS中的抗脑抗体提供了有价值的线索。
