Ryberg B, Jacque C
Acta Neurol Scand. 1986 Mar;73(3):247-52. doi: 10.1111/j.1600-0404.1986.tb03270.x.
The dysmyelinating mouse mutant Shiverer has a severe and relatively selective deficiency of myelin basic protein (MBP) in the central and peripheral nervous system. Nevertheless, Shiverer brain and control-mouse brain showed similar antigenic titers when tested by a complement fixation assay against a panel of 14 multiple sclerosis (MS) sera and 6 MS CSF samples known to represent several specificities of antibrain antibodies. By analogy with experimental allergic encephalomyelitis, a sensitization to MBP has been proposed in MS. Our results, however, show that antibodies to other CNS antigens are quantitatively more important in this disease.
脱髓鞘小鼠突变体“颤抖者”在中枢和外周神经系统中存在严重且相对选择性的髓鞘碱性蛋白（MBP）缺乏。然而，当用补体结合试验针对一组14份多发性硬化症（MS）血清和6份已知代表几种抗脑抗体特异性的MS脑脊液样本进行检测时，“颤抖者”小鼠脑和对照小鼠脑显示出相似的抗原滴度。类比实验性变应性脑脊髓炎，有人提出MS中存在对MBP的致敏作用。然而，我们的结果表明，针对其他中枢神经系统抗原的抗体在这种疾病中在数量上更为重要。
