Swain S L, Dutton R W, Schwab R, Yamamoto J
J Exp Med. 1983 Feb 1;157(2):720-9. doi: 10.1084/jem.157.2.720.
Human T cells respond strongly to mouse major histocompatibility complex (MHC) antigens. The response is directed predominantly to the polymorphic determinants of the MHC antigens and there is little or no response to the nonpolymorphic determinants or to non-MHC antigens. Human cytotoxic T lymphocytes (CTL) are generated specific for the mouse class I MHC antigens and the CTL effectors are blocked by anti-Leu-2a antisera. Human interleukin 2-producing T cells are generated specific for mouse class II antigens and their induction is blocked by anti-Leu-3a antisera. These and other considerations lead us to propose a model for the T cell receptor that provides an explanation for several of the features of T cell recognition. In this model, the recognition of the "class" (I or II) of MHC antigen is separate from the recognition of the polymorphic determinants. We suggest that the initial recognition of the conserved "class" determinants positions another domain of the receptor so that it can only engage with the part of the MHC molecule carrying the polymorphic determinants.
人类T细胞对小鼠主要组织相容性复合体（MHC）抗原反应强烈。这种反应主要针对MHC抗原的多态性决定簇，对非多态性决定簇或非MHC抗原几乎没有反应。产生了针对小鼠I类MHC抗原的特异性人类细胞毒性T淋巴细胞（CTL），并且CTL效应细胞被抗Leu - 2a抗血清阻断。产生了针对小鼠II类抗原的特异性产生白细胞介素2的人类T细胞，并且它们的诱导被抗Leu - 3a抗血清阻断。这些以及其他因素促使我们提出一个T细胞受体模型，该模型为T细胞识别的几个特征提供了解释。在这个模型中，对MHC抗原“类别”（I类或II类）的识别与对多态性决定簇的识别是分开的。我们认为，对保守的“类别”决定簇的初始识别会使受体的另一个结构域定位，以便它只能与携带多态性决定簇的MHC分子部分结合。
