Morimoto N, Ozawa M, Nishimura R, Hamamoto T, Tojo S
Obstet Gynecol. 1983 Mar;61(3):379-83.
Ectopic production of isolated alpha-subunit of glycoprotein hormones was detected in a 32-year-old Japanese woman with metastatic lung tumor by a discordance in the immunologic pregnancy tests for native human chorionic gonadotropin (hCG) assays. Quantitative discrepancy of titrations among different types of pregnancy tests, ie, competitive (hemagglutination or latexagglutination inhibition) and noncompetitive (hemagglutination or latexagglutination) reactions, was also confirmed experimentally using a highly purified ectopic alpha-subunit from the patient's urine. Thus the discrepancy between the 2 types of assay systems was due, at least partly, to a cross-reaction of high concentrations (20,000 ng/ml) of ectopically secreted free alpha-subunit of glycoprotein hormones.
在一名患有转移性肺肿瘤的32岁日本女性中，通过对天然人绒毛膜促性腺激素（hCG）检测的免疫妊娠试验结果不一致，检测到了糖蛋白激素分离的α亚基的异位产生。使用从患者尿液中高度纯化的异位α亚基进行实验，还证实了不同类型妊娠试验（即竞争性[血凝或乳胶凝集抑制]和非竞争性[血凝或乳胶凝集]反应）之间滴定的定量差异。因此，这两种检测系统之间的差异至少部分是由于异位分泌的高浓度（20,000 ng/ml）糖蛋白激素游离α亚基的交叉反应所致。
