Bruccoleri F, Zepponi E, Balucanti F, Ciciarelli U, Di Donna G, Di Folco S, Mascelli A
Quad Sclavo Diagn. 1982 Mar;18(1):67-75.
Many authors proposed erythrocytes discriminating functions to differentiate most common microcythemic hypochromic anemias (beta-thalassemia and iron deficiency). This study considers two of these discriminating functions: 1. Mentzer's index; 2. Srivastava's index; and also test GLT50 proposed by Authors with the same aim. The purpose is to quantify the percent of false positive and false negative results of such tests. As standard the test of measurement HbA2 and HbF was used to classify thalassemic patients. The results prove that the Mentzer test is the best while, not highly specific (20% false positive), but we did not find any false negatives in our study. Srivastava's method for the presence of false negatives (7% of thalassemic patients) is less reliable, and even less so the GLT50 test (30% of thalassemic patients).
许多作者提出通过红细胞鉴别功能来区分最常见的小细胞低色素性贫血（β地中海贫血和缺铁性贫血）。本研究考量了其中两种鉴别功能：1. 门泽指数；2. 斯里瓦斯塔瓦指数；同时还测试了作者们出于相同目的提出的GLT50。目的是量化此类检测假阳性和假阴性结果的百分比。作为标准，使用测量HbA2和HbF的检测来对地中海贫血患者进行分类。结果证明，门泽检测是最佳的，虽然特异性不高（20%假阳性），但在我们的研究中未发现任何假阴性。斯里瓦斯塔瓦方法存在假阴性（7%的地中海贫血患者），可靠性较低，GLT50检测更是如此（30%的地中海贫血患者）。
