Posteraro A, Gottfried E L
Am J Clin Pathol. 1978 Oct;70(4):637-41. doi: 10.1093/ajcp/70.4.637.
The predictive value of a prolonged glycerol lysis time (GLT50) was assessed by analysis of case records of 100 consecutive subjects with values greater than 73 seconds (normal = 26--73 seconds) reported by the clinical laboratory of The New York Hospital. There were 72 cases of hemoglobinopathy: 65 thalassemia trait, four sickle-thalassemia, and one each of Hb D-thalassemia, sickle-C disease, and sickle-cell anemia. Nine of the remaining subjects had iron-deficiency anemia, three had chronic renal disease, and seven had miscellaneous disorders. Four subjects were apparently normal, and in five cases there was insufficient information for a diagnosis. Of 78 patients who had both a prolonged GLT50 and microcytosis, 67 (86%) had thalassemia trait and seven (9%) had iron-deficiency anemia. In 74 patients with GLT50 greater than 100 seconds, thalassemia trait was found 16 times as often as uncomplicated iron-deficiency anemia. All 31 subjects with GLT50 greater than 180 seconds had hemoglobinopahy. A prolonged GLT50 strongly suggests thalassemia trait, especially when greater than 100 seconds or associated with microcytosis.
通过分析纽约医院临床实验室报告的100例连续受试者（甘油溶解时间(GLT50)超过73秒，正常范围为26 - 73秒）的病例记录，评估了延长的甘油溶解时间(GLT50)的预测价值。其中有72例血红蛋白病患者：65例为地中海贫血特征，4例为镰状细胞 - 地中海贫血，1例为Hb D - 地中海贫血、1例为镰状细胞C病和1例镰状细胞贫血。其余受试者中，9例患有缺铁性贫血，3例患有慢性肾病，7例患有其他杂症。4名受试者看似正常，5例因信息不足无法诊断。在78例GLT50延长且有小红细胞症的患者中，67例(86%)为地中海贫血特征，7例(9%)为缺铁性贫血。在GLT50大于100秒的74例患者中，地中海贫血特征的出现频率是单纯缺铁性贫血的16倍。所有GLT50大于180秒的31名受试者均患有血红蛋白病。延长的GLT50强烈提示地中海贫血特征，尤其是当大于100秒或与小红细胞症相关时。
