Micu D, Vilău C, Mihăilescu E, Guran M, Olinescu V, Constantineanu I
Med Interne. 1982 Jul-Sep;20(3):239-42.
The area of lymphocyte nucleoli (ALN) is a recently imagined method (Micu et al., 1978) which can detect cytochemically the microscopically visible surface of nucleolar RNA, measurable in mu2. The normal ALN value in peripheral blood is 84.4 +/- 9.2 mu2. Using in vitro cultures of PHA-stimulated lymphocytes obtained from 106 patients with various internal diseases, the authors could demonstrate a relationship between the rate of the lymphocytic RNA biosynthesis and the ALN variations, namely that an RNA hyper- or hyposynthesis is accompanied by an increase or a decrease, respectively, of the ALN.
淋巴细胞核仁面积（ALN）是一种最近设想出的方法（米库等人，1978年），它可以通过细胞化学方法检测核仁RNA在显微镜下可见的表面，以平方微米（μm²）为单位进行测量。外周血中正常的ALN值为84.4±9.2μm²。作者利用从106例患有各种内科疾病的患者身上获取的经PHA刺激的淋巴细胞进行体外培养，证明了淋巴细胞RNA生物合成速率与ALN变化之间的关系，即RNA合成亢进或减退分别伴随着ALN的增加或减少。
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