[Effect of supernatant from PHA-stimulated lymphocyte culture on blastic transformation of peripheral blood lymphocytes in healthy controls and patients with chronic lymphatic leukemia].

It was found that supernatant from a PHA-stimulated 3-day-old culture of peripheral blood lymphocytes of healthy people had the ability of stimulating blastic transformation of peripheral blood lymphocytes of other healthy people. The same amount of supernatant caused a much lower blastic transformation of peripheral blood lymphocytes from patients with chronic lymphatic leukaemia. The tested supernatant caused no increase in the degree of blastic transformation of PHA-stimulated lymphocytes from patients with chronic lymphatic leukaemia.