Leier C V, Meacham J A, Schaal S F
Circulation. 1978 Feb;57(2):213-6. doi: 10.1161/01.cir.57.2.213.
Electrophysiological studies were performed during sinus rhythm on 21 patients who had demonstrated the spontaneous occurrence of sustained atrial flutter. The purpose was to determine if atrial conduction disease is a prediposing factor for the development of atrial flutter. Patients with atrial enlargement were excluded from the series. The control group consisted of 11 age-matched patients with normal electrocardiograms and electrophysiology studies. The flutter group showed prolongation of the mean right intra-atrial conduction time at 50 msec (control of 37 msec, P less than 0.05), the mean interatrial conduction time at 92 msec (control of 44 msec, P less than 0.001) and the mean P wave duration at 132 msec (control of 112 msec, P less than 0.01). The flutter group also demonstrated a higher incidence of sinus node dysfunction and ventricular conduction disease compared to the control group. These data indicate that patients who develop atrial flutter have atrial conduction disease. Atrial conduction disease appears to be 1) a major prediposing factor for the development of atrial flutter and 2) a part of the fibro-degenerative conduction disease spectrum.
对21例曾出现过持续性心房扑动自发发作的患者在窦性心律时进行了电生理研究。目的是确定心房传导疾病是否是心房扑动发生的一个 predisposing 因素。该系列研究排除了心房扩大的患者。对照组由11例年龄匹配、心电图和电生理研究正常的患者组成。心房扑动组的平均右心房内传导时间延长至50毫秒（对照组为37毫秒，P<0.05），平均房间传导时间延长至92毫秒（对照组为44毫秒，P<0.001），平均P波时限延长至132毫秒（对照组为112毫秒，P<0.01）。与对照组相比，心房扑动组还表现出更高的窦房结功能障碍和心室传导疾病发生率。这些数据表明，发生心房扑动的患者存在心房传导疾病。心房传导疾病似乎是1）心房扑动发生的一个主要 predisposing 因素，2）纤维变性传导疾病谱的一部分。 （注：“predisposing”未找到完全准确对应中文词汇，这里暂保留英文）
