Pearson J C, Dombrovskis S, Dreyer J, Williams R D
Urology. 1983 Jan;21(1):37-41. doi: 10.1016/0090-4295(83)90119-x.
The effect of prostatic massage on the concentration of prostatic acid phosphatase (PAP) in blood serum as determined by radioimmunoassay (RIA) was compared with that determined by a standard enzymatic assay (EA). Serum was drawn from 24 men before prostatic massage and after--at specified intervals, up to twenty-four hours. Three of these men were young, normal controls; 10 had biopsy-proved prostate cancer (CA); 11 had histologically confirmed benign prostatic hyperplasia (BPH). After prostatic massage, 3 of the 10 CA patients (30%) had elevation of PAP as determined by EA and 4 of the 11 BPH patients (36%) as determined by RIA. None of the controls showed elevated levels of PAP by either assay. In all patients elevated levels of PAP by both assays had returned to normal twenty-four hours after massage. It was concluded that serum for PAP testing by either assay method should be drawn before or twenty-four hours after rectal examination to prevent false positive results and the need for retesting.
通过放射免疫测定法（RIA）测定前列腺按摩对血清中前列腺酸性磷酸酶（PAP）浓度的影响，并与标准酶法（EA）测定的结果进行比较。在前列腺按摩前和按摩后的特定时间间隔内，直至24小时，从24名男性身上采集血清。其中3名男性为年轻正常对照；10名经活检证实患有前列腺癌（CA）；11名经组织学证实患有良性前列腺增生（BPH）。前列腺按摩后，10名CA患者中有3名（30%）经EA测定PAP升高，11名BPH患者中有4名（36%）经RIA测定PAP升高。两种检测方法均未显示任何对照的PAP水平升高。在所有患者中，两种检测方法检测到的PAP升高水平在按摩后24小时均恢复正常。得出结论，为防止出现假阳性结果和再次检测的需要，应在直肠检查前或24小时后采集用于两种检测方法检测PAP的血清。
