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[通过免疫吸附研究人和动物甲型流感病毒血凝素的抗原相似性]

[Antigenic similarity of the hemagglutinins of human and animal influenza A viruses studied by immunoadsorption].

作者信息

Zakstel'skaia L Ia, Shenderovich S F, Iakhno M A, Isachenko V A, Zhdanov V M

出版信息

Vopr Virusol. 1980 May-Jun(3):287-90.

PMID:6159729
Abstract

Antigenic relationships between human influenza A viruses containing hemagglutinins of HO and H1 subtypes and animal and avian influenza viruses Hsw1 and Hav5 were studied by immunoadsorption using inorganic base of the sorbent. Direct and indirect relations due to the presence in hemagglutinin of common antigenic determinants and hapten groups were revealed. The strains representing drift variations within one subtype differed by the spectrum of hapten determinants typical of other subtypes. No common determinant typical for all members of this group was isolated.

摘要

利用吸附剂的无机碱通过免疫吸附研究了含有HO和H1亚型血凝素的人类甲型流感病毒与动物和禽流感病毒Hsw1和Hav5之间的抗原关系。揭示了由于血凝素中存在共同抗原决定簇和半抗原基团而产生的直接和间接关系。代表同一亚型内漂移变异的毒株,其半抗原决定簇谱与其他亚型典型的不同。未分离出该组所有成员共有的典型决定簇。

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