Ershov F I, Nosik N N, Tazulakhova E B
Biull Eksp Biol Med. 1983 Feb;95(2):66-8.
The rates and time course of interferon production in mice administered nine inductors of different nature were studied and compared. Use was made of the most prospective synthetic and natural polymers as well as of low-molecular preparations. It was established that polymers bring about early interferon production with a peak being reached in 4-6 hours, followed by rapid disappearance. Low-molecular inductors are marked by late interferon production, with the maximal titers attained in 24-48 hours, followed by prolonged circulation (4 days of observation).
研究并比较了给小鼠注射九种不同性质的诱导剂后干扰素产生的速率和时间进程。使用了最具前景的合成聚合物和天然聚合物以及低分子制剂。结果表明,聚合物可引起早期干扰素产生,在4 - 6小时达到峰值,随后迅速消失。低分子诱导剂的特点是干扰素产生较晚,在24 - 48小时达到最大滴度,随后循环时间延长(观察4天)。