Kileny P, Dobson D, Gelfand E T
Electroencephalogr Clin Neurophysiol. 1983 Mar;55(3):268-76. doi: 10.1016/0013-4694(83)90204-3.
Middle-latency auditory evoked responses (MLRs) were recorded from infants and adults before and during open heart surgery. Hypothermia was induced through perfusion cooling by cardiopulmonary bypass. In infants deep hypothermia (to 15 degrees C nasopharyngeal temp.) was often followed by the induction of total circulatory arrest. In adults nasopharyngeal temperatures of 25 degrees C were reached. The MLRs were elicited by unfiltered clicks presented through an insert type earphone and recorded with a vertex to ipsilateral earlobe electrode configuration. The MLRs proved to be resistant to muscle relaxation induced by pancuronium and to anesthesia induced and maintained in most cases by fentanyl. In most cases MLR peak latencies were progressively delayed as temperature decreased. Hypotension resulted in decreased MLR (Pa) amplitude.
在心脏直视手术前及手术过程中，记录了婴儿和成人的中潜伏期听觉诱发电位（MLRs）。通过体外循环灌注冷却诱导体温过低。在婴儿中，深度低温（鼻咽温度降至15摄氏度）常继之以诱导完全循环停止。在成人中，鼻咽温度达到25摄氏度。MLRs由通过插入式耳机呈现的未滤波短声诱发，并采用头顶至同侧耳垂电极配置进行记录。结果表明，MLRs对泮库溴铵诱导的肌肉松弛以及大多数情况下由芬太尼诱导和维持的麻醉具有抗性。在大多数情况下，随着温度降低，MLR峰值潜伏期逐渐延迟。低血压导致MLR（Pa）波幅降低。
