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高效液相色谱法与自动荧光法测定神经组织和脑脊液中多巴胺、3,4-二羟基苯乙酸、高香草酸和5-羟吲哚乙酸的相关性

Correlation between high-performance liquid chromatography and automated fluorimetric methods for the determination of dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindoleacetic acid in nervous tissue and cerebrospinal fluid.

作者信息

Westerink B H

出版信息

J Chromatogr. 1982 Dec 10;233:69-77. doi: 10.1016/s0378-4347(00)81732-6.

DOI:10.1016/s0378-4347(00)81732-6
PMID:6186680
Abstract

The correlation between automated fluorimetric methods and high-performance liquid chromatography is described for the determination of homovanillic acid and 5-hydroxyindoleacetic acid in cerebrospinal fluid, and for dopamine, 3,4-dihydroxyphenylacetic acid and homovanillic acid in striata of rat brain. The automated fluorimetric methods for 3,4-dihydroxyphenylacetic acid and homovanillic acid showed a good correlation with the high-performance liquid chromatographic methodology. The fluorimetric determination for dopamine was somewhat less reliable than the high-performance liquid chromatographic assay. The fluorimetric assay for 5-hydroxyindoleacetic acid correlated poorly with the chromatographic method.

摘要

本文描述了自动荧光法与高效液相色谱法之间的相关性，用于测定脑脊液中的高香草酸和5-羟吲哚乙酸，以及大鼠脑纹状体中的多巴胺、3,4-二羟基苯乙酸和高香草酸。3,4-二羟基苯乙酸和高香草酸的自动荧光法与高效液相色谱法显示出良好的相关性。多巴胺的荧光测定法比高效液相色谱法可靠性稍差。5-羟吲哚乙酸的荧光测定法与色谱法的相关性较差。

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Correlation between high-performance liquid chromatography and automated fluorimetric methods for the determination of dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindoleacetic acid in nervous tissue and cerebrospinal fluid.高效液相色谱法与自动荧光法测定神经组织和脑脊液中多巴胺、3,4-二羟基苯乙酸、高香草酸和5-羟吲哚乙酸的相关性
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