Densen P, Brown E J, O'Neill G J, Tedesco F, Clark R A, Frank M M, Webb D, Myers J
J Clin Immunol. 1983 Jan;3(1):90-9. doi: 10.1007/BF00919144.
An adult male with recurrent meningococcal infections is reported whose serum lacked functional C8 activity but possessed antigenic C8. The addition of 1500 U of purified C8/ml of serum restored hemolytic activity to normal. Four to five times more C8 was required to restore bactericidal activity than to restore hemolytic activity. Bactericidal activity could also be restored by mixing the patient's serum with a second C8-deficient serum that lacked detectable antigenic or functional C8. The patient's serum contained bactericidal antibody for groups A, B, C, and Y meningococci and specific antibody to group Y capsular polysaccharide. There was two to three times more bactericidal antibody activity in the serum than in a pool of normal sera for the infecting strain. Family studies disclosed a sibling who was HLA identical to the patient but whose serum contained normal amounts of total hemolytic and C8 functional activity.
据报道，一名成年男性反复发生脑膜炎球菌感染，其血清缺乏功能性C8活性，但含有抗原性C8。每毫升血清中加入1500 U纯化C8可使溶血活性恢复正常。恢复杀菌活性所需的C8量是恢复溶血活性所需量的4至5倍。将患者血清与第二种缺乏可检测到的抗原性或功能性C8的C8缺陷血清混合，也可恢复杀菌活性。患者血清中含有针对A、B、C和Y群脑膜炎球菌的杀菌抗体以及针对Y群荚膜多糖的特异性抗体。血清中的杀菌抗体活性比感染菌株的正常血清池高两到三倍。家族研究发现一名与患者HLA相同的同胞，但其血清中总溶血活性和C8功能活性含量正常。
