苯巴比妥、扑米酮和苯妥英的实用常规气相色谱测定法。
A practical routine gas chromatographic determination of phenobarbital, primidone and diphenylhydantoin.
作者信息
Malkus H, Jatlow P I, Castro A
出版信息
Clin Chim Acta. 1978 Jan 2;82(1-2):113-7. doi: 10.1016/0009-8981(78)90033-5.
PMID:618673
Abstract
A gas chromatographic method for the routine determination of phenobarbital, primidone and diphenylhydantoin using alkaline extraction and on-column methylation has been developed. The procedure has been optimized for recovery of all three anticonvulsant drugs with particular attention to primidone. Correlation with photometric methods for phenobarbital and diphenylhydantoin show the technique offers significant advantages in both accuracy and precision over other methods.
摘要
已开发出一种气相色谱法，用于常规测定苯巴比妥、扑米酮和苯妥英，该方法采用碱性萃取和柱上甲基化。该程序已针对所有三种抗惊厥药物的回收率进行了优化，尤其关注扑米酮。与苯巴比妥和苯妥英的光度法的相关性表明，该技术在准确性和精密度方面比其他方法具有显著优势。
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