Ida S, Siraganian R P, Notkins A L
J Gen Virol. 1983 Mar;64 Pt 3:533-7. doi: 10.1099/0022-1317-64-3-533.
Mice immunized with ultraviolet-inactivated herpes simplex virus (HSV) or injected with infectious virus developed IgE-specific antibody to HSV. Cell-bound IgE was detected by measuring the release of histamine from peritoneal mast cells challenged in vitro with virus antigens. Circulating IgE antibody was detected by sensitizing rat basophilic leukaemia (RBL-2H3) cells with sera from HSV-immunized mice and then challenging these cells with virus or control antigens to release histamine. IgE antibody may contribute to the pathogenesis of virus infections.
用紫外线灭活的单纯疱疹病毒（HSV）免疫的小鼠或注射感染性病毒的小鼠产生了针对HSV的IgE特异性抗体。通过测量用病毒抗原体外攻击的腹膜肥大细胞中组胺的释放来检测细胞结合的IgE。通过用HSV免疫小鼠的血清使大鼠嗜碱性白血病（RBL-2H3）细胞致敏，然后用病毒或对照抗原攻击这些细胞以释放组胺来检测循环IgE抗体。IgE抗体可能有助于病毒感染的发病机制。
