Gibbons A E, Price P, Robertson T A, Papadimitriou J M, Shellam G R
Department of Microbiology, University of Western Australia, Nedlands.
Arch Virol. 1990;115(3-4):299-307. doi: 10.1007/BF01310538.
Mast cells purified from the peritoneal cell population and mast cells derived in culture from bone marrow cells were examined for their sensitivity to murine cytomegalovirus (MCMV) infection in vitro. While up to 70% of mast cells expressed viral antigens, less than 12% of the cells produced infectious virus. Transmission electron microscopy demonstrated nucleocapsids in the nuclei and in association with the cisternal elements of the Golgi apparatus. Some complete virions were found within small cytoplasmic vacuoles. In contrast with previous studies of macrophages and fibroblasts, the susceptibility of mast cells to MCMV infection in vitro was not influenced by the H-2 or non-H-2 genotype of the donor.
对从腹膜细胞群体中纯化得到的肥大细胞以及从骨髓细胞培养衍生而来的肥大细胞进行体外检测，观察它们对鼠巨细胞病毒（MCMV）感染的敏感性。虽然高达70%的肥大细胞表达病毒抗原，但产生传染性病毒的细胞不到12%。透射电子显微镜显示核衣壳存在于细胞核中，并与高尔基体的潴泡成分相关。在小的细胞质空泡内发现了一些完整的病毒粒子。与先前对巨噬细胞和成纤维细胞的研究不同，肥大细胞在体外对MCMV感染的易感性不受供体的H-2或非H-2基因型的影响。
