Clumeck N, Steens M, Englert Y, Butzler J P
Scand J Infect Dis. 1982;14(4):283-8. doi: 10.3109/inf.1982.14.issue-4.07.
The sensitivity of blood culture isolates to the bactericidal activity of normal human serum (NHS) has been studied in 101 patients with gram-negative sepsis. These results were compared with clinical status and outcome, and to the presence of specific IgG or IgM antibodies to O antigens of bacteraemic strains in autologous serum. 23% of the strains were markedly resistant, 27% markedly sensitive and 50% intermediately sensitive to the bactericidal activity of NHS. Shock or death occurred more frequently in immunocompromised patients and those infected with serum-resistant strains. IgG antibody titres to O antigens were significantly lower in patients with serum-resistant organisms regardless of their immune status. Resistance to natural bactericidal antibodies and low immunogenicity of the infecting organism, plus immunodeficiency in the host, may account for apparent increased virulence of some gram-negative bacilli.
对101例革兰氏阴性菌败血症患者血液培养分离菌对正常人血清（NHS）杀菌活性的敏感性进行了研究。将这些结果与临床状态和转归进行比较，并与自体血清中针对菌血症菌株O抗原的特异性IgG或IgM抗体的存在情况进行比较。23%的菌株对NHS的杀菌活性明显耐药，27%明显敏感，50%中度敏感。免疫功能低下的患者以及感染血清耐药菌株的患者更常发生休克或死亡。无论免疫状态如何，血清耐药菌患者中针对O抗原的IgG抗体滴度均显著较低。对天然杀菌抗体的耐药性、感染病原体的低免疫原性以及宿主的免疫缺陷，可能是某些革兰氏阴性杆菌毒力明显增加的原因。
