Frithz A, Lagerholm B, Kaaman T
Acta Derm Venereol. 1982;62(6):521-5.
A case of genital leukoderma syphiliticum was analysed submicroscopically. No treponema pallidum organisms could be detected intra- or extracellularly in the epidermis or in the dermis. The melanocytes were only slightly reduced in number and had mostly normal outlines. The melanogenesis was impaired and small melanosomes with decreased deposition of melanin were mostly produced at the expense of normal melanin granules. A partial block in the melanin transfer mechanism seems to be in evidence. As no direct destructive action of spirochetes on the melanocytes is observed, an indirect effect is assumed, e.g. by a tyrosinase inhibitor.
对1例梅毒性生殖器白斑进行了亚显微镜分析。在表皮或真皮内，细胞内或细胞外均未检测到梅毒螺旋体。黑素细胞数量仅略有减少，且大多轮廓正常。黑素生成受损，主要产生的是黑色素沉积减少的小黑素体，而正常的黑色素颗粒减少。黑色素转运机制似乎存在部分阻滞。由于未观察到螺旋体对黑素细胞有直接破坏作用，推测存在间接效应，例如通过酪氨酸酶抑制剂。
