白癜风性色素脱失合并恶性黑色素瘤中的巨大黑色素颗粒。
Giant melanin granules in vitiliginous achromia with malignant melanoma.
作者信息
Ortonne J P, Perrot H
出版信息
Acta Derm Venereol. 1978;58(6):475-80.
PMID:83067
Abstract
Histological and ultrastructural examination of normal and perilesional skin of a patient with vitiliginous depigmentation associated with a malignant melanoma revealed the presence of giant melanin granules in keratinocytes and melanocytes. These structures are compared to macromelanosomes which have been observed in numerous pigmentary diseases. The formation and significance of the giant melanin granules is discussed.
摘要
对一名患有与恶性黑色素瘤相关的白癜风性色素脱失患者的正常皮肤和病损周围皮肤进行组织学和超微结构检查，发现角质形成细胞和黑素细胞中存在巨大黑色素颗粒。将这些结构与在多种色素性疾病中观察到的巨大黑素小体进行了比较。讨论了巨大黑色素颗粒的形成及其意义。
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