Mengersen R, Schick R, Kölsch E
Eur J Immunol. 1975 Aug;5(8):532-7. doi: 10.1002/eji.1830050805.
The preferential take of tumors after small-size inocula of transplantable tumor cells has been described for many systems. The phenomenon has been named "sneaking through" or "dilution escape". Using a BALB/c mastocytoma, we have analyzed the immunological parameters accompanying sneaking through that can be observed upon injection of 10(1) to 10(3) living cells. Mice can also be conditioned by injection of low, subimmunogenic numbers of irradiated cells to show increased tumor incidences upon injection of living cells in doses two orders of magnitude above the sneaking through dose. The general immune reactivity of the animals is not impaired under these conditions. However, determinant-specific unresponsiveness is found which can be transferred by spleen cells and therefore seems to be actively maintained. It is concluded that sneaking through of tumor cells is the result of specific immunological impairment of the host's immune system by subimmunogenic small-size inocula of tumor cells.
对于许多系统而言，可移植肿瘤细胞小剂量接种后肿瘤的优先生长情况已有描述。这一现象被称为“潜行通过”或“稀释逃逸”。我们使用BALB/c肥大细胞瘤，分析了在注射10¹至10³个活细胞时可观察到的伴随潜行通过的免疫学参数。通过注射低剂量、亚免疫原性数量的辐照细胞对小鼠进行预处理，可使小鼠在注射剂量比潜行通过剂量高两个数量级的活细胞时，肿瘤发生率增加。在这些条件下，动物的一般免疫反应性并未受损。然而，发现了决定簇特异性无反应性，这种无反应性可通过脾细胞转移，因此似乎是被主动维持的。得出的结论是，肿瘤细胞的潜行通过是宿主免疫系统被亚免疫原性小剂量肿瘤细胞接种特异性免疫损伤的结果。
