Gordon H A, Rovin S, Bruckner G
Gerontology. 1978;24(1):1-11. doi: 10.1159/000212231.
In oral tissues of rats, progress of age resulted in a gradual reduction of regional blood flow and in decreased levels of eluable (labile) hydroxyproline from the collagen component. These were paralleled by an increment of salivary kallikrein. The presence of the microbial flora in the oral cavity, portrayed by the comparison of conventional and germfree rats, caused an elevation of blood flow in all age groups, without exerting a marked effect on eluable hydroxyproline. In addition to aging and flora effects, the action of chronic hypoxia and of mechanical stress has been observed on the mentioned parameters. The presently used animal models and experimental design permit a critical study of etiologic agents and characteristic lesions of peridontal disease.
在大鼠口腔组织中，随着年龄增长，局部血流逐渐减少，胶原蛋白成分中可洗脱（不稳定）羟脯氨酸水平降低。这些变化与唾液激肽释放酶的增加同时出现。通过对常规饲养大鼠和无菌大鼠的比较可以看出，口腔微生物菌群的存在会使所有年龄组的血流量增加，但对可洗脱羟脯氨酸没有显著影响。除了衰老和菌群的影响外，还观察到慢性缺氧和机械应力对上述参数的作用。目前使用的动物模型和实验设计有助于对牙周病的病因和特征性病变进行批判性研究。
