Namba M, Miyoshi T, Kanamori T, Nobuhara M, Kimoto T, Ogawa S
Gan. 1982 Oct;73(5):819-24.
The growth inhibitory effects of the combination of 5-fluorouracil (5-FU) and human fibroblast interferon on human neoplastic cell lines and normal human fibroblasts were examined. The neoplastic cell lines used were HeLa (cervical carcinoma), MCF-7 (mammary carcinoma), WI-38 CT-1 (embryonic lung fibroblasts transformed in culture by 60Co gamma-ray irradiation), KMM-1 (myeloma), and Raji (Burkitt's lymphoma). The normal human cell line used was WI-38. The growth inhibitory effects were determined by measuring colony formation for HeLa, MCF-7, WI-38 CT-1, and WI-38 cells, and by measuring cell growth for KMM-1 and Raji cells. Each cell line showed different sensitivities to 5-FU or interferon. The combination of 5-FU and interferon showed synergistic inhibitory effects on the growth of HeLa, WI-38 CT-1, KMM-1, and Raji cells. Neither synergistic nor additive growth inhibitory effects of the combination of 5-FU and interferon were observed in MCF-7 and WI-38 cells.
研究了5-氟尿嘧啶（5-FU）与人成纤维细胞干扰素联合使用对人肿瘤细胞系和正常人成纤维细胞的生长抑制作用。所用的肿瘤细胞系有HeLa（宫颈癌）、MCF-7（乳腺癌）、WI-38 CT-1（经60Coγ射线照射在培养中转化的胚胎肺成纤维细胞）、KMM-1（骨髓瘤）和Raji（伯基特淋巴瘤）。所用的正常人细胞系是WI-38。通过测量HeLa、MCF-7、WI-38 CT-1和WI-38细胞的集落形成，以及测量KMM-1和Raji细胞的细胞生长来确定生长抑制作用。每种细胞系对5-FU或干扰素表现出不同的敏感性。5-FU和干扰素联合使用对HeLa、WI-38 CT-1、KMM-1和Raji细胞的生长显示出协同抑制作用。在MCF-7和WI-38细胞中未观察到5-FU和干扰素联合使用的协同或相加生长抑制作用。
