猪胃底因子、生长抑素、P物质、胰高血糖素、神经降压素、蛙皮素、血管活性肠肽、胃动素和五肽胃泌素对大鼠空肠葡萄糖吸收的影响。
Effects of porcine gastric fundic factor, somatostatin, substance P, glucagon, neurotensin, bombesin, VIP, motilin, and pentagastrin on jejunal glucose absorption in the rat.
作者信息
Andrews N J, Rinno-Barmada S, Burdett K, Elder J B
出版信息
Gut. 1983 Apr;24(4):326-32. doi: 10.1136/gut.24.4.326.
The effects of a porcine gastric fundic mucosal extract (molecular weight less than 10 000) has been compared with the effects of eight candidate gastrointestinal peptides on glucose absorption from the jejunum in a rat model. Bolus injection of the extract produced immediate and marked depression of glucose absorption. None of the candidate peptides tested produced this response, although somatostatin and substance P depressed absorption as a late phenomenon after 30 minutes. We conclude that the effects of the fundic extract are not reproduced by any of these candidate peptides. This strengthens the evidence for a novel gastrointestinal peptide, resident in fundic mucosa, which affects absorption from upper small bowel.
在大鼠模型中，已将猪胃底黏膜提取物（分子量小于10000）的作用与8种候选胃肠肽对空肠葡萄糖吸收的作用进行了比较。推注该提取物可立即并显著抑制葡萄糖吸收。尽管生长抑素和P物质在30分钟后作为晚期现象可抑制吸收，但所测试的候选肽均未产生这种反应。我们得出结论，这些候选肽均未重现胃底提取物的作用。这进一步证明了存在于胃底黏膜中的一种新型胃肠肽，它可影响上小肠的吸收。
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