神经递质和肽对大鼠门静脉纵行肌和环行肌的作用。

Actions of neurotransmitters and peptides on longitudinal and circular muscle of the rat portal vein.

作者信息

Mathison R

出版信息

J Pharm Pharmacol. 1983 Jan;35(1):34-7. doi: 10.1111/j.2042-7158.1983.tb04259.x.

DOI:10.1111/j.2042-7158.1983.tb04259.x

Abstract

The reactivity of longitudinal and circular muscle of the rat portal vein to noradrenaline, acetylcholine, 5-hydroxytryptamine, substance P, angiotensin II and neurotensin was compared. Longitudinal muscle was prepared as longitudinal strips and circular muscle was studied as transversally cut rings. Longitudinal muscle was more sensitive than circular muscle to acetylcholine, 5-hydroxytryptamine and angiotensin II, whereas both muscle layers were equally sensitive to noradrenaline and substance P. Circular muscle was generally unresponsive to neurotensin. Differential sensitivity of longitudinal and circular muscle layers suggests that these two muscle layers do not necessarily operate in unison.

摘要

比较了大鼠门静脉纵行肌和环行肌对去甲肾上腺素、乙酰胆碱、5-羟色胺、P物质、血管紧张素II和神经降压素的反应性。纵行肌制备成纵行条带，环行肌则作为横向切割的环进行研究。纵行肌对乙酰胆碱、5-羟色胺和血管紧张素II比环行肌更敏感，而两层肌肉对去甲肾上腺素和P物质的敏感性相同。环行肌通常对神经降压素无反应。纵行肌层和环行肌层的敏感性差异表明，这两层肌肉不一定协同运作。