Dudar T E, Jain R K
Microvasc Res. 1983 Jan;25(1):1-21. doi: 10.1016/0026-2862(83)90040-7.
Red blood cell (RBC) velocities, lumen diameters, and volumetric flow rates were determined as functions of position and time in the microvessels of repairing tissue grown in a transparent rabbit ear chamber. By making repeated measurements in the same region, and in many instances, in exactly the same vessel over the entire growth period, we have discerned a distinct microcirculatory flow trend. The flow to a particular region (vessel) increases rapidly after an initial lag time, peaks out, and eventually decays to a steady-state level. This behavior is analogous to the vessel density pattern previously observed in this laboratory, but is delayed in time 1 to 2 weeks. These observations are consistent with mechanical, biochemical, and physiological mechanisms underlying neovascularization, tissue growth, and blood flow regulation, and provide a quantitative understanding of these processes.
在透明兔耳腔中生长的修复组织的微血管中，测定了红细胞（RBC）速度、管腔直径和体积流量随位置和时间的变化。通过在同一区域进行重复测量，并且在许多情况下，在整个生长期间对完全相同的血管进行测量，我们发现了一种明显的微循环血流趋势。在初始滞后时间后，流向特定区域（血管）的血流迅速增加，达到峰值，最终衰减至稳态水平。这种行为类似于先前在本实验室观察到的血管密度模式，但在时间上延迟1至2周。这些观察结果与新生血管形成、组织生长和血流调节的机械、生化和生理机制一致，并为这些过程提供了定量的理解。
