Mizejewski G J, Carter T P, Beblowski D W, Bellisario R
Pediatr Res. 1983 Jan;17(1):47-50. doi: 10.1203/00006450-198301000-00009.
Serum alpha-fetoprotein (AFP) concentrations were measured in dried blood spots and the biologic half-life of AFP was determined during the first month after parturition. AFP blood levels, in babies at all birthweight groups during the first wk, were partitioned according to birthweight and sex. A synthetic surge of serum AFP at postnatal day 3 was observed in babies of the low birthweight category (less than 6 lb 8 oz), whereas a concomitant surge could not be demonstrated in babies of medium, (6 lb 8 oz to 8 lb 8 oz), and high birthweight, (greater than 8 lb 8 oz), categories. All babies weighing less than 6 lb 8 oz, regardless of prematurity likewise displayed the synthetic surge. The sex of the infant appeared to have no influence on AFP serum concentrations. In a population of infants ranging in age from 1-30 days, the biologic apparent half-life of AFP was calculated as 5.7 days; however, the half-life of AFP was found to differ among the three groups of infants when subdivided by birthweight and was higher (7.7 days) in babies of low birthweight. Our determination of 2 S.D. cutoff values for AFP in the first wk of life should prompt further studies in which the relationship of AFP to newborn disorders should be more fully explored.
在干血斑中测量血清甲胎蛋白（AFP）浓度，并在分娩后的第一个月内测定AFP的生物学半衰期。在出生后第一周，根据出生体重和性别对所有出生体重组婴儿的AFP血水平进行划分。在低出生体重类别（小于6磅8盎司）的婴儿中观察到出生后第3天血清AFP的合成激增，而在中等出生体重（6磅8盎司至8磅8盎司）和高出生体重（大于8磅8盎司）类别的婴儿中未发现相应的激增。所有体重小于6磅8盎司的婴儿，无论是否早产，同样表现出合成激增。婴儿的性别似乎对AFP血清浓度没有影响。在年龄为1至30天的婴儿群体中，AFP的生物学表观半衰期计算为5.7天；然而，当按出生体重细分时，发现AFP的半衰期在三组婴儿中有所不同，低出生体重婴儿的半衰期更高（7.7天）。我们对出生后第一周AFP的2个标准差临界值的测定应促使进一步研究，其中应更全面地探讨AFP与新生儿疾病的关系。
