Blohm M E, Vesterling-Hörner D, Calaminus G, Göbel U
Department of Paediatric Haematology and Oncology, Children's Hospital, Heinrich Heine University Medical Centre, Düsseldorf, Germany.
Pediatr Hematol Oncol. 1998 Mar-Apr;15(2):135-42. doi: 10.3109/08880019809167228.
The aim of this study was to establish reference values and factors associated with serum AFP elevation in infants. Five hundred twenty-four samples collected from infants up to the age of 2 years at the University Hospital Düsseldorf (Germany) were analyzed. At birth mean serum AFP levels were 41,687 ng/ml in 256 term babies and 158,125 ng/ml in 90 premature babies born before the 37th gestational week, excluding samples from children with factors known to be associated with AFP elevation. In the first 4 weeks of life, AFP levels decreased by 50% in 5.1 days in term babies. Between day 180 and 720 of life, AFP levels up to 87 ng/ml were within the 95.5% interval (assumed logarithmic normal distribution) with a mean of 8 ng/ml without a further decline. By the age of 2 years the infants of this study had not reached adult serum AFP levels (0-6 ng/ml).
本研究的目的是确定婴儿血清甲胎蛋白（AFP）升高的参考值及相关因素。对德国杜塞尔多夫大学医院收集的524份2岁以下婴儿的样本进行了分析。出生时，256名足月儿的平均血清AFP水平为41,687 ng/ml，90名孕37周前出生的早产儿的平均血清AFP水平为158,125 ng/ml，不包括已知与AFP升高相关因素的儿童样本。在出生后的前4周，足月儿的AFP水平在5.1天内下降了50%。在出生后第180天至720天之间，AFP水平高达87 ng/ml处于95.5%区间内（假设为对数正态分布），平均为8 ng/ml，且未进一步下降。到2岁时，本研究中的婴儿尚未达到成人血清AFP水平（0 - 6 ng/ml）。
