Obiekwe B C, Malek N, Kitau M J, Chard T
Acta Obstet Gynecol Scand. 1985;64(3):251-3. doi: 10.3109/00016348509155123.
Serum alpha-fetoprotein (AFP) was measured in maternal, cord arterial and venous blood. Samples were collected at the time of vaginal delivery from 105 women at 36-42 weeks' gestation. There was a significant correlation between maternal, cord arterial and venous AFP. Umbilical cord arterial and venous AFP levels were considerably higher in male infants than in females. Umbilical AFP levels declined with lengthening gestation and increasing birthweight for both male and female infants and a similar pattern was seen in the mother. Fetal AFP levels were significantly higher in subjects giving birth at 40 weeks whose infants had a birthweight below the population mean vis-à-vis those above the mean. It is concluded that the absolute size of the fetus as well as gestational age may play a significant role in determining maternal and fetal AFP concentration.
在母体、脐动脉和脐静脉血中检测血清甲胎蛋白（AFP）。在妊娠36 - 42周时，于阴道分娩时从105名妇女采集样本。母体、脐动脉和脐静脉AFP之间存在显著相关性。男性婴儿的脐动脉和脐静脉AFP水平明显高于女性。对于男婴和女婴，脐AFP水平均随孕周延长和出生体重增加而下降，母亲中也观察到类似模式。与出生体重高于平均水平的相比，在40周分娩且婴儿出生体重低于总体平均水平的受试者中，胎儿AFP水平显著更高。得出的结论是，胎儿的绝对大小以及胎龄在决定母体和胎儿AFP浓度方面可能起重要作用。
