人白细胞干扰素和阿糖腺苷治疗单纯疱疹病毒性脑炎的试验：诊断与治疗问题

Trial with human leucocyte interferon and vidarabine in herpes simplex virus encephalitis: diagnostic and therapeutic problems.

作者信息

Koskiniemi M L, Vaheri A, Valtonen S, Haltia M, Kaste M, Manninen V, Salonen E M, Icén A, Cantell K

出版信息

Acta Med Scand Suppl. 1982;668:150-60. doi: 10.1111/j.0954-6820.1982.tb08538.x.

DOI:10.1111/j.0954-6820.1982.tb08538.x

Abstract

A combination therapy of human interferon, vidarabine, and dexamethasone was administered to six patients with proven (Patients I-III) or presumed (Patients IV-VI) herpes simplex virus encephalitis (HSVE). Interferon combined with dexamethasone was given to one patient with presumed HSVE (Patient VII). Leucopenia and elevated serum transaminase levels appeared in all patients and a diffuse bleeding in one of them. Patients II, III and IV died, 26, 43, and 209 days after the onset of encephalitis, respectively. Patients I, V, VI, and VII were left with moderate brain damage although their physical condition was good. HSV encephalitis presents diagnostic difficulties, complementary diagnostic methods are needed, and current therapeutic trials must be considered as preliminary.

摘要

对6例确诊（患者I - III）或疑似（患者IV - VI）单纯疱疹病毒性脑炎（HSVE）的患者采用人干扰素、阿糖腺苷和地塞米松联合治疗。对1例疑似HSVE的患者（患者VII）给予干扰素联合地塞米松治疗。所有患者均出现白细胞减少和血清转氨酶水平升高，其中1例出现弥漫性出血。患者II、III和IV分别在脑炎发病后26、43和209天死亡。患者I、V、VI和VII虽身体状况良好，但仍遗留中度脑损伤。HSV脑炎存在诊断困难，需要补充诊断方法，目前的治疗试验必须视为初步的。