Noetzel M J, Dodson W E
Ann Neurol. 1983 Apr;13(4):457-60. doi: 10.1002/ana.410130416.
Inosiplex has been utilized in the treatment of subacute sclerosing panencephalitis (SSPE), though without unequivocally established beneficial effect. We report a patient whose computerized tomographic (CT) scans demonstrated the development of progressive cerebral atrophy and multifocal white matter lesions despite continuous treatment with inosiplex and periods of considerable clinical improvement or stabilization. The findings suggest that inosiplex may not have altered the pathological consequences of SSPE and that clinical staging categories alone may not be reliable long-term correlates of the progression of the disease. Controlled studies utilizing assessment of brain mass by CT scan or other imaging devices in addition to clinical staging are required to evaluate the efficacy of inosiplex.
肌苷已被用于治疗亚急性硬化性全脑炎（SSPE），尽管其有益效果尚未明确确立。我们报告了一名患者，尽管持续使用肌苷治疗且有相当长一段时间临床症状改善或稳定，但计算机断层扫描（CT）显示其出现了进行性脑萎缩和多灶性白质病变。这些发现表明，肌苷可能并未改变SSPE的病理后果，而且仅靠临床分期类别可能无法可靠地长期反映疾病的进展情况。需要进行对照研究，除了临床分期外，还利用CT扫描或其他成像设备评估脑容量，以评估肌苷的疗效。
