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肌苷治疗亚急性硬化性全脑炎

Inosiplex in the treatment of subacute sclerosing panencephalitis.

作者信息

Silverberg R, Brenner T, Abramsky O

出版信息

Arch Neurol. 1979 Jun;36(6):374-5. doi: 10.1001/archneur.1979.00500420084012.

DOI:10.1001/archneur.1979.00500420084012
PMID:88215
Abstract

Six patients with subacute sclerosing panencephalitis were treated with the antiviral agent inosiplex. The clinical condition of four children continued to deteriorate in spite of the treatment, the condition of one remained unchanged, and that of another improved minimally. The effect of inosiplex in these patients is not evident since this group demonstrated a pattern of progression similar to that seen in subacute sclerosing panencephalitis without specific treatment.

摘要

六名亚急性硬化性全脑炎患者接受了抗病毒药物肌苷片的治疗。尽管进行了治疗,四名儿童的临床状况仍持续恶化,一名儿童的状况保持不变,另一名儿童的状况仅有轻微改善。肌苷片对这些患者的疗效并不明显,因为该组患者的病情进展模式与未经特殊治疗的亚急性硬化性全脑炎患者相似。

相似文献

1
Inosiplex in the treatment of subacute sclerosing panencephalitis.肌苷治疗亚急性硬化性全脑炎
Arch Neurol. 1979 Jun;36(6):374-5. doi: 10.1001/archneur.1979.00500420084012.
2
[The effect of inosiplex in subacute sclerosing panencephalitis (SSPE)].[肌苷片在亚急性硬化性全脑炎(SSPE)中的作用]
No To Hattatsu. 1984 Jul;16(4):262-70.
3
The effect of inosiplex on the survival of subacute sclerosing panencephalitis.肌苷对亚急性硬化性全脑炎存活情况的影响。
Neurology. 1983 Aug;33(8):1053-5. doi: 10.1212/wnl.33.8.1053.
4
Long-term follow-up of patients with subacute sclerosing panencephalitis treated with inosiplex.用肌苷治疗的亚急性硬化性全脑炎患者的长期随访
Ann Neurol. 1982 Apr;11(4):359-64. doi: 10.1002/ana.410110407.
5
Treatment of subacute sclerosing panencephalitis: an overview.亚急性硬化性全脑炎的治疗:综述
Drug Intell Clin Pharm. 1984 May;18(5):375-81. doi: 10.1177/106002808401800503.
6
Inosiplex therapy in subacute sclerosing panencephalitis. A multicentre, non-randomised study in 98 patients.肌苷治疗亚急性硬化性全脑炎。一项针对98例患者的多中心、非随机研究。
Lancet. 1982 May 8;1(8280):1034-7. doi: 10.1016/s0140-6736(82)92097-9.
7
Inosiplex for SSPE.肌苷多聚磷酸酯用于亚急性硬化性全脑炎
Lancet. 1982 Aug 28;2(8296):495. doi: 10.1016/s0140-6736(82)90521-9.
8
Inosiplex for SSPE.肌苷治疗亚急性硬化性全脑炎。
Lancet. 1982 Jun 26;1(8287):1475. doi: 10.1016/s0140-6736(82)92488-6.
9
The influence of inosiplex treatment on the neurological disability of patients with subacute sclerosing panencephalitis.肌苷治疗对亚急性硬化性全脑炎患者神经功能障碍的影响。
J Pediatr. 1982 Aug;101(2):288-93. doi: 10.1016/s0022-3476(82)80143-1.
10
Clinical effects of MND-19 (Inosiplex) on subacute sclerosing panencephalitis--a multi-institutional collaborative study--The Inosiplex-SSPE Research Committee.MND-19(肌苷)对亚急性硬化性全脑炎的临床疗效——一项多机构合作研究——肌苷-亚急性硬化性全脑炎研究委员会
Brain Dev. 1987;9(3):270-82. doi: 10.1016/s0387-7604(87)80044-x.

引用本文的文献

1
Disease-Modifying Therapy in Subacute Sclerosing Panencephalitis: An Area of Darkness.亚急性硬化性全脑炎的疾病修饰治疗:一个未知领域。
Ann Indian Acad Neurol. 2023 Jan-Feb;26(1):3-9. doi: 10.4103/aian.aian_655_22. Epub 2023 Jan 25.
2
Inosine Pranobex Deserves Attention as a Potential Immunomodulator to Achieve Early Alteration of the COVID-19 Disease Course.肌苷普拉诺昔布作为一种潜在的免疫调节剂值得关注,以实现 COVID-19 病程的早期改变。
Viruses. 2021 Nov 9;13(11):2246. doi: 10.3390/v13112246.
3
Inosine Pranobex: A Key Player in the Game Against a Wide Range of Viral Infections and Non-Infectious Diseases.
肌苷普乐安:对抗多种病毒感染和非传染性疾病的关键药物。
Adv Ther. 2019 Aug;36(8):1878-1905. doi: 10.1007/s12325-019-00995-6. Epub 2019 Jun 5.
4
Subacute sclerosing panencephalitis.亚急性硬化性全脑炎
J Neurol. 2008 Dec;255(12):1861-71. doi: 10.1007/s00415-008-0032-6. Epub 2008 Oct 14.
5
Subacute sclerosing panencephalitis: results of the Canadian Paediatric Surveillance Program and review of the literature.亚急性硬化性全脑炎:加拿大儿科监测项目的结果及文献综述
BMC Pediatr. 2005 Dec 15;5:47. doi: 10.1186/1471-2431-5-47.
6
A placebo-controlled trial of isoprinosine in patients with multiple sclerosis.一项针对多发性硬化症患者的异搏定安慰剂对照试验。 (注:原文中的“isoprinosine”一般译为“异丙肌苷” ,这里根据你要求不能添加解释就按你提供英文单词直接翻译了,实际医学领域一般用标准译名“异丙肌苷” 。)
J Neurol Neurosurg Psychiatry. 1994 Feb;57(2):164-8. doi: 10.1136/jnnp.57.2.164.
7
Cerebrospinal fluid IgG changes in subacute sclerosing panencephalitis in the various stages of the disease and during isoprinosine therapy.亚急性硬化性全脑炎在疾病各阶段及异丁司特治疗期间脑脊液IgG的变化。
Ital J Neurol Sci. 1981 May;2(2):177-84. doi: 10.1007/BF02335441.
8
Use of isoprinosine in subacute sclerosing panencephalitis.异博定在亚急性硬化性全脑炎中的应用。
Arch Dis Child. 1980 Oct;55(10):829-30. doi: 10.1136/adc.55.10.829-a.
9
Inosine pranobex. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.异丙肌苷。对其药效学、药代动力学特性及治疗效果的初步综述。
Drugs. 1986 Nov;32(5):383-424. doi: 10.2165/00003495-198632050-00001.
10
Subacute sclerosing panencephalitis.亚急性硬化性全脑炎
Br Med J. 1979 Nov 3;2(6198):1096.