Davies J E, Marsden C A, Roberts M H
Brain Res. 1983 Feb 14;261(1):59-68. doi: 10.1016/0006-8993(83)91283-0.
Unilateral lesions of the dorsolateral funiculus (DLF) in the rat resulted in unilateral hyperalgesia as revealed by a hindpaw withdrawal test to heat. Larger lesions involving the dorsal column and ventrolateral quadrant did not cause hyperalgesia. The levels of 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), noradrenaline (NA) and dopamine (DA) were measured in the lumbar dorsal quadrant using high performance liquid chromatography (HPLC). In hyperalgesic animals DLF lesions caused an ipsilateral reduction of all the amines and a contralateral reduction of 5-HT and NA. This suggests that serotonergic and noradrenergic axons in the DLF give a contralateral innervation. A correlation was sought between the reduction of amine level and the degree of hyperalgesia shown by individual rats on lesioned and unlesioned sides of the cord. No consistent correlation was found with any of the amines.
大鼠背外侧索（DLF）的单侧损伤导致单侧痛觉过敏，这通过后爪对热的退缩试验得以揭示。涉及背柱和腹外侧象限的较大损伤并未引起痛觉过敏。使用高效液相色谱法（HPLC）测量了腰背部象限中5-羟色胺（5-HT）、5-羟吲哚乙酸（5-HIAA）、去甲肾上腺素（NA）和多巴胺（DA）的水平。在痛觉过敏的动物中，DLF损伤导致所有胺类物质同侧减少，5-HT和NA对侧减少。这表明DLF中的血清素能和去甲肾上腺素能轴突提供对侧神经支配。研究了胺水平的降低与个体大鼠脊髓损伤侧和未损伤侧所表现出的痛觉过敏程度之间的相关性。未发现与任何一种胺类有一致的相关性。
