Imanishi J, Hoshino S, Matsuoka H, Uemura H, Imanishi T, Kishida T
C R Seances Soc Biol Fil. 1982;176(6):894-7.
The target cells (KB, HeLa, FL, human hepatoma and murine L929) were cocultured with human embryonic fibroblasts in the Petri dish. The degenerative changes of the target cells except L929 cells by the human fibroblasts were found. Human leukocyte interferon (HuIFN-alpha) and human fibroblast interferon (HuIFN-beta) enhanced these changes, but mouse IFN (MuIFN-alpha, beta) did not. The other human fibroblasts also caused the degenerative changes of the target cell, and HuIFN-alpha enhanced these changes. It was concluded that human fibroblasts play a certain role in the suppression of the human tumor cell.
将靶细胞（KB、HeLa、FL、人肝癌细胞和小鼠L929细胞）与人胚胎成纤维细胞在培养皿中共培养。发现人成纤维细胞可引起除L929细胞外的靶细胞发生退行性变化。人白细胞干扰素（HuIFN-α）和人成纤维细胞干扰素（HuIFN-β）可增强这些变化，但小鼠干扰素（MuIFN-α、β）则无此作用。其他人类成纤维细胞也可引起靶细胞的退行性变化，且HuIFN-α可增强这些变化。得出结论：人成纤维细胞在抑制人肿瘤细胞方面发挥一定作用。
