Williams R C
Hum Pathol. 1983 May;14(5):386-91. doi: 10.1016/s0046-8177(83)80282-2.
Human rheumatoid factors are antibodies of IgG, IgA, or IgM class that show reactions with antigenic determinants present on other immunoglobulin molecules. The most commonly measured rheumatoid factor relates to the 19S IgM type, which reacts by agglutination of latex particles coated with 7S IgG and is often measured in the standard latex fixation test. Approximately 65 to 70 per cent of patients with rheumatoid arthritis show positive serologic tests for rheumatoid factor; however, a number of other chronic disease conditions are also associated with positive rheumatoid factor reactions, including infective endocarditis, sarcoidosis, leprosy, and other hyperglobulinemic conditions. Although extensive serologic and immunochemical studies have identified a number of specific antigenic structural sites on immunoglobulin molecules that react with rheumatoid factors, recent studies have shown that a certain proportion of such antibodies may show cross-reactivity with DNA-histone complexes as well. It is still not entirely clear how rheumatoid factors fit into the pathogenesis of rheumatoid arthritis itself.
人类类风湿因子是IgG、IgA或IgM类抗体，可与其他免疫球蛋白分子上的抗原决定簇发生反应。最常检测的类风湿因子与19S IgM型有关，它通过凝集包被有7S IgG的乳胶颗粒来发生反应，并且常在标准乳胶凝集试验中进行检测。大约65%至70%的类风湿关节炎患者类风湿因子血清学检测呈阳性；然而，许多其他慢性疾病状况也与类风湿因子阳性反应有关，包括感染性心内膜炎、结节病、麻风病以及其他高球蛋白血症状况。尽管广泛的血清学和免疫化学研究已经确定了免疫球蛋白分子上一些与类风湿因子发生反应的特定抗原结构位点，但最近的研究表明，一定比例的此类抗体也可能与DNA - 组蛋白复合物发生交叉反应。类风湿因子如何参与类风湿关节炎本身的发病机制仍不完全清楚。
