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类风湿关节炎和亚急性细菌性心内膜炎中19S和7S抗γ球蛋白的轻链异质性

Light chain heterogeneity of 19S and 7S anti-gamma-globulins in rheumatoid arthritis and subacute bacterial endocarditis.

作者信息

Carson D A, Lawrance S

出版信息

Arthritis Rheum. 1978 May;21(4):438-40. doi: 10.1002/art.1780210406.

DOI:10.1002/art.1780210406
PMID:418786
Abstract

Both 19S and 7S anti-gamma-globulins in rheumatoid arthritis sera are enriched in kappa light chain bearing antibody molecules when compared to total 19S and 7S globulins from the same individuals. In patients with subacute bacterial endocarditis 19S anti-gamma-globulins are also, to a degree, enriched in kappa light chains, whereas the 7S anti-gamma-globulins have kappa to lambda light chain ratios indistinguishable from total 7S globulin.

摘要

与来自相同个体的总19S和7S球蛋白相比，类风湿性关节炎血清中的19S和7S抗γ球蛋白富含携带κ轻链的抗体分子。在亚急性细菌性心内膜炎患者中，19S抗γ球蛋白在一定程度上也富含κ轻链，而7S抗γ球蛋白的κ轻链与λ轻链的比例与总7S球蛋白无法区分。

相似文献

1
Light chain heterogeneity of 19S and 7S anti-gamma-globulins in rheumatoid arthritis and subacute bacterial endocarditis.类风湿关节炎和亚急性细菌性心内膜炎中19S和7S抗γ球蛋白的轻链异质性
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引用本文的文献

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Physiology and pathology of rheumatoid factors.类风湿因子的生理学与病理学
Springer Semin Immunopathol. 1981;4(2):161-79. doi: 10.1007/BF01857093.
2
IgM-rheumatoid factors cross-reactive with IgG and a cell nuclear antigen: immunopathological implications?与IgG和一种细胞核抗原发生交叉反应的IgM类风湿因子：免疫病理学意义？
Ann Rheum Dis. 1980 Dec;39(6):586-8. doi: 10.1136/ard.39.6.586.
3
Subclass restriction and polyclonality of the systemic lupus erythematosus marker antibody anti-Sm.系统性红斑狼疮标志物抗体抗Sm的亚类限制和多克隆性。
J Clin Invest. 1985 Apr;75(4):1270-7. doi: 10.1172/JCI111826.
4
Enzyme-linked immunosorbent assay (ELISA) screening test for detection of rheumatoid factor.
Rheumatol Int. 1986;6(5):199-204. doi: 10.1007/BF00541367.
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The common occurrence of internal image type anti-idiotypic antibodies in rabbits immunized with monoclonal and polyclonal human IgM rheumatoid factors.在用单克隆和多克隆人IgM类风湿因子免疫的兔子中，内部图像型抗独特型抗体的常见出现情况。
Clin Exp Immunol. 1986 Jun;64(3):570-80.
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Immunology. 1987 Dec;62(4):529-36.
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Scand J Immunol. 1992 Jul;36(1):57-61. doi: 10.1111/j.1365-3083.1992.tb02940.x.
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