Olsen R G, Du Plessis D, Barron C, Schulz E J, Villet W
J Clin Lab Immunol. 1983 Feb;10(2):103-6.
Lichen planus is a common papulosquamous disorder of skin and mucous membranes of unknown etiology. Studies reported here demonstrate a lichen planus specific antigen (LPSA) in granular and deep prickle epithelial cells from the lichen planus lesion. Sera from seven out of eight lichen planus patients tested contained an antibody to LPSA. The LPSA was not detected in normal skin tissues from lichen planus patients, or in skin from normal donors and skin from patients with skin disorders other than lichen planus. A serologic survey of serum from people with no clinical history of lichen planus revealed approximately a 7% incidence of antibody to LPSA. These studies suggest that LPSA may be of exogenous origin.
扁平苔藓是一种病因不明的常见皮肤和黏膜丘疹鳞屑性疾病。此处报道的研究表明，在扁平苔藓病变的颗粒层和深部棘层上皮细胞中存在一种扁平苔藓特异性抗原（LPSA）。在检测的8例扁平苔藓患者中，有7例患者的血清含有抗LPSA抗体。在扁平苔藓患者的正常皮肤组织、正常供体的皮肤以及除扁平苔藓外的其他皮肤病患者的皮肤中均未检测到LPSA。对无扁平苔藓临床病史人群的血清进行血清学调查发现，抗LPSA抗体的发生率约为7%。这些研究表明，LPSA可能来源于外源性。
