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一段1.7千碱基的小鼠乳腺肿瘤病毒特异性RNA的结构分析

Structural analysis of a 1.7-kilobase mouse mammary tumor virus-specific RNA.

作者信息

van Ooyen A J, Michalides R J, Nusse R

出版信息

J Virol. 1983 May;46(2):362-70. doi: 10.1128/JVI.46.2.362-370.1983.

DOI:10.1128/JVI.46.2.362-370.1983
PMID:6188860
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC255137/
Abstract

We have detected a mouse mammary tumor virus (MMTV)-specific 1.7-kilobase (kb) polyadenylated RNA in mammary glands of several mouse strains. In BALB/c mice, it is the only MMTV-specific RNA species present. C3H and GR mammary glands and tumors contain, in addition, 3.8- and 7.8-kb MMTV RNAs. Nuclease S1 analysis was performed to map 1.7-kb polyadenylated RNA. It contains predominantly long terminal repeat (LTR) sequences. The 5' end maps approximately 134 nucleotides upstream from the 3' end of the LTR. Colinearity with complete proviral DNA continues to a site about 153 nucleotides downstream from the left (5') LTR. No sequences from the middle part of proviral DNA were found. Colinearity with proviral DNA is resumed 72 nucleotides upstream from the right (3') LTR. The nucleotide sequence in this area is TTCCAGT, which is a splice acceptor consensus sequence. The anatomy of 1.7-kb RNA indicates that it may serve as a messenger for the 36,700-dalton protein encoded by the LTRs of MMTV.

摘要

我们在几种小鼠品系的乳腺中检测到了一种小鼠乳腺肿瘤病毒（MMTV）特异性的1.7千碱基（kb）多聚腺苷酸化RNA。在BALB/c小鼠中，它是唯一存在的MMTV特异性RNA种类。此外，C3H和GR小鼠的乳腺及肿瘤中还含有3.8 kb和7.8 kb的MMTV RNA。进行了核酸酶S1分析以绘制1.7 kb多聚腺苷酸化RNA的图谱。它主要包含长末端重复序列（LTR）。5'端位于LTR 3'端上游约134个核苷酸处。与完整前病毒DNA的共线性一直延伸到左（5'）LTR下游约153个核苷酸处。未发现前病毒DNA中间部分的序列。与前病毒DNA的共线性在右（3'）LTR上游72个核苷酸处恢复。该区域的核苷酸序列为TTCCAGT，这是一个剪接受体共有序列。1.7 kb RNA的结构表明它可能作为MMTV LTR编码的36,700道尔顿蛋白质的信使。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b661/255137/65021de4b89c/jvirol00146-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b661/255137/1abcd231d3c8/jvirol00146-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b661/255137/851c4e079009/jvirol00146-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b661/255137/47fd28eb2e06/jvirol00146-0042-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b661/255137/e14cc0935607/jvirol00146-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b661/255137/65021de4b89c/jvirol00146-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b661/255137/1abcd231d3c8/jvirol00146-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b661/255137/851c4e079009/jvirol00146-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b661/255137/47fd28eb2e06/jvirol00146-0042-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b661/255137/e14cc0935607/jvirol00146-0043-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b661/255137/65021de4b89c/jvirol00146-0044-a.jpg

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本文引用的文献

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Long terminal repeats of endogenous mouse mammary tumour virus contain a long open reading frame which extends into adjacent sequences.内源性小鼠乳腺肿瘤病毒的长末端重复序列包含一个延伸至相邻序列的长开放阅读框。
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