Whiting R B, Madigan N P, Heinemann F M, Curtis J J, Reid J
Pacing Clin Electrophysiol. 1983 Mar;6(2 Pt 1):242-6. doi: 10.1111/j.1540-8159.1983.tb04352.x.
Nine patients with programmable atrioventricular sequential pacers were studied using systolic time intervals (QS2--the total electrical and mechanical systole, left ventricular ejection time, and pre-ejection period). These measurements were obtained by simultaneous recording of the electrocardiogram, phonocardiogram, and carotid pulse tracing. There was a dramatic fall of left ventricular ejection time (LVET) and an increase of the pre-ejection time (PEP) in all patients when the pacers were programmed from the atrioventricular to the ventricular mode at constant heart rate. This resulted in an increase of the ratio PEP/LVET from .428 to .574 suggesting loss of ventricular function. These measurements all reversed to baseline values when the pacers were re-programmed back to the atrioventricular mode. This study suggests systolic time intervals might be useful to select non-invasively pacer parameters such as mode, rate, and effective PR interval in order to provide the best hemodynamics in a given patient.
我们使用收缩期时间间期（QS2，即总的电和机械收缩期、左心室射血时间及射血前期）对9名植入可编程房室顺序起搏器的患者进行了研究。这些测量值通过同步记录心电图、心音图和颈动脉脉搏描记图获得。当起搏器以恒定心率从房室模式程控为心室模式时，所有患者的左心室射血时间（LVET）显著下降，射血前期（PEP）延长。这导致PEP/LVET比值从0.428增加到0.574，提示心室功能丧失。当起搏器重新程控回房室模式时，这些测量值均恢复到基线值。本研究提示，收缩期时间间期可能有助于无创地选择起搏器参数，如模式、心率和有效PR间期，以便在特定患者中提供最佳血流动力学。
