Rak K, Beck P, Udvardy M, Pfliegler G, Misz M, Boda Z
Thromb Res. 1983 Jan 15;29(2):155-62. doi: 10.1016/0049-3848(83)90137-8.
In order to investigate the relationship between the in vivo platelet activation in diabetes mellitus and the endothelial damage connected with the diabetic micro- and/or macroangiopathy, plasma levels of beta-thromboglobulin (B-TG) and of factor VIII-related antigen (VIII R:Ag) were studied (1) in juvenile-onset (Type I) diabetics without clinical signs of angiopathy (age under 12 years) and (2) in mostly maturity-onset (Type II) diabetics with and without overt angiopathy (age between 14 and 60 years). Normal controls and nondiabetics with atherosclerosis were also studied. Plasma levels of both proteins were found to be elevated in all the groups of diabetic and atherosclerotic patients in comparison with the controls. Highest levels were found in adult diabetics with angiopathy and in atherosclerotics even without diabetes, but values of the diabetic children were also elevated. The data suggest a causal relationship between the vascular damage and the enhanced platelet reactivity in which the former may play the primary role.
为了研究糖尿病患者体内血小板活化与糖尿病微血管和/或大血管病变相关的内皮损伤之间的关系，我们对以下人群的血浆β-血小板球蛋白（B-TG）和因子VIII相关抗原（VIII R:Ag）水平进行了研究：（1）无血管病变临床症状的青少年发病（I型）糖尿病患者（年龄在12岁以下）；（2）大多为成年发病（II型）糖尿病患者，伴有或不伴有明显血管病变（年龄在14至60岁之间）。同时也研究了正常对照组以及患有动脉粥样硬化的非糖尿病患者。与对照组相比，所有糖尿病组和动脉粥样硬化患者组的这两种蛋白质的血浆水平均升高。血管病变的成年糖尿病患者以及即使无糖尿病的动脉粥样硬化患者中这两种蛋白质水平最高，但糖尿病儿童的水平也有所升高。这些数据表明血管损伤与血小板反应性增强之间存在因果关系，其中血管损伤可能起主要作用。
