Pedersen E B, Sølling J, Mogensen C E, Christensen K D
Acta Pathol Microbiol Immunol Scand C. 1982 Dec;90(6):301-5. doi: 10.1111/j.1699-0463.1982.tb01454.x.
Immune complexes in serum, urinary excretion of albumin and beta-2-microglobulin were determined in patients with infectious mononucleosis, both during the acute stage of the disease and one month later. At the first examination immune complexes were detected in 8 out of 12 patients, using both the ClqBA and the PP-Lc methods, but had disappeared in all after one month. Urinary excretion was initially increased for albumin in one of 9 and for beta-2-microglobulin in 5 of 9 patients. A significant fall in excretion was noted for beta-2-microglobulin during the acute phase (0.486 to 0.190 ng/min (medians), p less than 0.01) whereas albumin excretion did not change significantly (9.0 to 4.0 micrograms/min). Excretions were normal in all patients after one month. The magnitude of proteinuria was not correlated to the serum level of immune complexes. Serum beta-2-microglobulin was initially increased in 8 of 9 patients, but normal after one month (3.8 to 2.2 mg/l, p less than 0.01). There was a significant correlation between levels of beta-2-microglobulin in serum and urine (rho = 0.833, n = 9, p less than 0.01). 51Cr-EDTA clearance was the same during the acute illness and one month later. It is concluded that the abnormalities in urinary protein excretion do not seem to be related to the presence of circulating immune complexes in infectious mononucleosis and that the elevated urinary beta-2-microglobulin excretion is most likely due to increase production.
在感染性单核细胞增多症患者的疾病急性期及一个月后，测定了血清中的免疫复合物、白蛋白尿排泄及β2-微球蛋白尿排泄。首次检查时，采用ClqBA和PP-Lc两种方法，在12例患者中的8例检测到免疫复合物，但一个月后所有患者的免疫复合物均消失。9例患者中，1例白蛋白尿排泄最初增加，5例β2-微球蛋白尿排泄最初增加。急性期β2-微球蛋白排泄显著下降（中位数从0.486降至0.190 ng/min，p<0.01），而白蛋白排泄无显著变化（从9.0降至4.0 μg/min）。一个月后所有患者的排泄均恢复正常。蛋白尿程度与血清免疫复合物水平无关。9例患者中，8例血清β2-微球蛋白最初升高，但一个月后恢复正常（从3.8降至2.2 mg/l，p<0.01）。血清和尿液中的β2-微球蛋白水平之间存在显著相关性（rho = 0.833，n = 9，p<0.01）。急性疾病期间及一个月后的51Cr-EDTA清除率相同。结论是，感染性单核细胞增多症患者尿蛋白排泄异常似乎与循环免疫复合物的存在无关，尿β2-微球蛋白排泄升高很可能是由于产生增加所致。
