Chyrssanthopoulos C, Barboriak J J, Fink J N, Stekiel W J, Maksud M G
J Allergy Clin Immunol. 1978 Jan;61(1):17-22. doi: 10.1016/0091-6749(78)90468-2.
The response of the adrenergic system of asthmatic subjects to exercise and the role of plasma catecholamines in exercise-induced asthma were investigated. Plasma levels of norepinephrine and epinephrine were measured at rest, during and after exercise in 7 asthmatic and 9 matched normal subjects. Exercise-induced bronchospasm occurred in all asthmatic subjects following exercise, while no significant change was observed in the normal subjects. The results showed that plasma levels of norepinephrine and epinephrine at rest and changes that occcurred during and after exercise were similar in both normal and asthmatic subjects. These data suggest that the adrenergic response of asthmatics to the same relative exercise stress as reflected in plasma catecholamine levels does not differ from that of normal subjects. It appears that changes in the circulating catecholamines do not play a significant role in the pathogenesis of exercised-induced asthma.
研究了哮喘患者肾上腺素能系统对运动的反应以及血浆儿茶酚胺在运动诱发哮喘中的作用。对7名哮喘患者和9名匹配的正常受试者在静息状态、运动期间和运动后测量了去甲肾上腺素和肾上腺素的血浆水平。所有哮喘患者运动后均出现运动诱发的支气管痉挛，而正常受试者未观察到显著变化。结果显示，正常受试者和哮喘患者静息时的去甲肾上腺素和肾上腺素血浆水平以及运动期间和运动后的变化相似。这些数据表明，哮喘患者对与血浆儿茶酚胺水平所反映的相同相对运动应激的肾上腺素能反应与正常受试者无异。看来循环儿茶酚胺的变化在运动诱发哮喘的发病机制中不起重要作用。
