Berkin K E, Walker G, Inglis G C, Ball S G, Thomson N C
Department of Respiratory Medicine, Western Infirmary, Glasgow.
Thorax. 1988 Apr;43(4):295-9. doi: 10.1136/thx.43.4.295.
A failure of the usual increase in plasma adrenaline and noradrenaline concentrations during submaximal exercise has been suggested as a contributory cause of exercise induced asthma. Six normal subjects and six asthmatic patients underwent a standard graded maximal exercise test. Measurements of oxygen consumption, minute ventilation, exercise time, blood lactate concentration, and heart rate indicated that the two groups achieved similarly high work loads during exercise. Mean FEV1 fell by 20% in asthmatic patients after exercise. Basal plasma adrenaline concentrations (nmol/l) increased in normal subjects from 0.05 to 2.7 and in asthmatic patients from 0.12 to 1.6 at peak exercise. Noradrenaline concentrations (nmol/l) increased in normal subjects from 2.0 to 14.3 and in asthmatic patients from 1.9 to 13.7 at peak exercise. The increases in adrenaline and noradrenaline in the asthmatic patients did not differ significantly from the increases in normal subjects. Thus a reduced sympathoadrenal response to exercise seems unlikely to be an important mechanism in the pathogenesis of exercise induced asthma.
次最大运动量运动期间血浆肾上腺素和去甲肾上腺素浓度未能像通常那样升高，这被认为是运动诱发哮喘的一个促成因素。六名正常受试者和六名哮喘患者进行了标准的分级最大运动量测试。对耗氧量、分钟通气量、运动时间、血乳酸浓度和心率的测量表明，两组在运动期间达到了相似的高工作量。运动后哮喘患者的平均第一秒用力呼气量（FEV1）下降了20%。在运动峰值时，正常受试者的基础血浆肾上腺素浓度（nmol/l）从0.05增加到2.7，哮喘患者从0.12增加到1.6。在运动峰值时，正常受试者的去甲肾上腺素浓度（nmol/l）从2.0增加到14.3，哮喘患者从1.9增加到13.7。哮喘患者肾上腺素和去甲肾上腺素的增加与正常受试者的增加没有显著差异。因此，运动时交感肾上腺反应降低似乎不太可能是运动诱发哮喘发病机制中的一个重要机制。
