Schouten T J, van den Broek P, Cremers C W, Jongerius C M, Meyer J W, Vooys G P
Arch Otolaryngol. 1983 May;109(5):289-91. doi: 10.1001/archotol.1983.00800190011003.
A squamous cell carcinoma of the bronchus developed in a patient during the course of juvenile laryngeal papillomatosis. This patient had received interferon treatment, which caused regression of the papillomas, but apparently had no influence on the progression of the bronchogenic squamous cell carcinoma. This suggests that interferons have an antiviral effect, but not an antitumor effect in the dosage used. No radiation therapy had been given in the past and no other carcinogenic factors are obvious. However, human papilloma viruses, which cause juvenile laryngeal papillomatosis, have been incriminated in the genesis of squamous cell carcinomas.
一名患有青少年喉乳头状瘤病的患者发生了支气管鳞状细胞癌。该患者曾接受干扰素治疗，治疗使乳头状瘤消退，但显然对支气管源性鳞状细胞癌的进展没有影响。这表明干扰素具有抗病毒作用，但在所使用的剂量下没有抗肿瘤作用。过去未进行过放射治疗，也没有明显的其他致癌因素。然而，导致青少年喉乳头状瘤病的人乳头瘤病毒已被认为与鳞状细胞癌的发生有关。
