Friedman S M, Thompson G S
J Exp Med. 1983 May 1;157(5):1675-80. doi: 10.1084/jem.157.5.1675.
Using a panel of partially cloned, OKT4+, DRw-1-specific, alloproliferative human T cell lines, we have identified two functionally restricted and reciprocating types of helper T cells. One provides major histocompatibility complex-restricted help for plaque-forming cell responses by DRw 1+ allogeneic B cells; the other preferentially amplifies the generation of allospecific cytotoxic T lymphocytes (CTL) from CTL precursors that have been suboptimally triggered by alloantigen.
利用一组部分克隆的、OKT4+、DRw-1特异性、同种异体增殖性人类T细胞系,我们鉴定出了两种功能受限且相互作用的辅助性T细胞类型。一种为DRw 1+同种异体B细胞的噬斑形成细胞反应提供主要组织相容性复合体限制的辅助;另一种则优先增强由同种异体抗原次优触发的细胞毒性T淋巴细胞(CTL)前体产生的同种特异性CTL的生成。