功能受限的、同种特异性的人类辅助性T细胞系，可增强B细胞或细胞毒性T细胞反应。
Functionally restricted, allospecific, human helper T cell lines that amplify either B cell or cytolytic T cell responses.
作者信息
Friedman S M, Thompson G S
出版信息
J Exp Med. 1983 May 1;157(5):1675-80. doi: 10.1084/jem.157.5.1675.
Abstract
Using a panel of partially cloned, OKT4+, DRw-1-specific, alloproliferative human T cell lines, we have identified two functionally restricted and reciprocating types of helper T cells. One provides major histocompatibility complex-restricted help for plaque-forming cell responses by DRw 1+ allogeneic B cells; the other preferentially amplifies the generation of allospecific cytotoxic T lymphocytes (CTL) from CTL precursors that have been suboptimally triggered by alloantigen.
摘要
利用一组部分克隆的、OKT4+、DRw-1特异性、同种异体增殖性人类T细胞系，我们鉴定出了两种功能受限且相互作用的辅助性T细胞类型。一种为DRw 1+同种异体B细胞的噬斑形成细胞反应提供主要组织相容性复合体限制的辅助；另一种则优先增强由同种异体抗原次优触发的细胞毒性T淋巴细胞（CTL）前体产生的同种特异性CTL的生成。
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Functionally restricted, allospecific, human helper T cell lines that amplify either B cell or cytolytic T cell responses.功能受限的、同种特异性的人类辅助性T细胞系，可增强B细胞或细胞毒性T细胞反应。
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引用本文的文献
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Amplification of altered self-reactive cytolytic T lymphocyte responses by cloned, allospecific human Th cells.通过克隆的同种特异性人Th细胞扩增改变的自身反应性细胞溶解性T淋巴细胞反应。
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本文引用的文献
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The differentiation and function of human T lymphocytes.人类T淋巴细胞的分化与功能。
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Specific anti-influenza virus antibody production in vitro by human peripheral blood mononuclear cells.人外周血单个核细胞在体外产生特异性抗流感病毒抗体
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Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency.既往健康的同性恋男性中的卡氏肺孢子虫肺炎和黏膜念珠菌病：一种新获得性细胞免疫缺陷的证据。
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Allospecific human T cell lines and clones which mediate HLA-DR restricted helper activity.
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Dissection of immunoregulatory subpopulations of T lymphocytes within the helper and suppressor sublineages in man.人体辅助性和抑制性亚谱系中T淋巴细胞免疫调节亚群的剖析。
J Immunol. 1982 Nov;129(5):1997-2000.
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A human helper T cell clone secreting both killer helper factor(s) and T cell-replacing factor(s).一种分泌杀伤辅助因子和T细胞替代因子的人辅助性T细胞克隆。
J Immunol. 1982 Jul;129(1):46-51.
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In vitro generation of antigen-specific hemolytic plaque-forming cells from human peripheral blood mononuclear cells.从人外周血单个核细胞体外生成抗原特异性溶血空斑形成细胞。
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