同一个人类同种异体反应性T细胞克隆既能辅助B淋巴细胞，又能辅助特异性细胞毒性前体细胞。

The same human alloreactive T cell clone can help both B lymphocytes and specific cytotoxic precursors.

作者信息

Ramarli D, Parodi B, Fabbi M, Corte G, Lanzavecchia A

出版信息

J Exp Med. 1984 Jan 1;159(1):318-23. doi: 10.1084/jem.159.1.318.

DOI:10.1084/jem.159.1.318

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187196/

Abstract

Human alloreactive proliferating T cell clones have been compared for their capacity to provide help for B cell activation and the generation of a specific cytotoxic response. The results demonstrate that, when triggered by the relevant alloantigen, the same T cell clone can induce a strong polyclonal B cell activation and serve as the only source of helper cells for the generation of a specific cytotoxic response by any source of CTL precursors against any stimulator cell present in culture.

摘要

已对人类同种异体反应性增殖性T细胞克隆进行了比较，以评估它们为B细胞激活提供帮助以及产生特异性细胞毒性反应的能力。结果表明，当受到相关同种异体抗原触发时，同一个T细胞克隆可诱导强烈的多克隆B细胞激活，并作为辅助细胞的唯一来源，使任何来源的CTL前体细胞针对培养中存在的任何刺激细胞产生特异性细胞毒性反应。

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1

The same human alloreactive T cell clone can help both B lymphocytes and specific cytotoxic precursors.同一个人类同种异体反应性T细胞克隆既能辅助B淋巴细胞，又能辅助特异性细胞毒性前体细胞。

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2

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4

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引用本文的文献

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2

Induced differentiation of a transformed clone of Ly-1+ B cells by clonal T cells and antigen.克隆性T细胞和抗原诱导Ly-1+B细胞转化克隆的分化。

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本文引用的文献

1

The differentiation and function of human T lymphocytes.人类T淋巴细胞的分化与功能。

Cell. 1980 Apr;19(4):821-7. doi: 10.1016/0092-8674(80)90072-0.

2

Human T cell subpopulations defined by a monoclonal antibody. II. Evidence for cell cooperation in the response to alloantigens and generation of cytolytic cells.由单克隆抗体界定的人类T细胞亚群。II. 同种异体抗原应答及溶细胞性细胞产生中细胞协作的证据

J Immunol. 1982 Jan;128(1):20-3.

3

Human T cell subpopulations defined by a monoclonal antibody. I. A small subset is responsible for proliferation to allogeneic cells or to soluble antigens and for helper activity for B cell differentiation.由单克隆抗体定义的人T细胞亚群。I. 一个小亚群负责对同种异体细胞或可溶性抗原的增殖以及对B细胞分化的辅助活性。

J Immunol. 1982 Jan;128(1):16-9.

4

MLC-derived human helper factor(s) that promote B cell differentiation: induction, functional characterization, and role of Ia antigens.源自人多能造血祖细胞的促进B细胞分化的辅助因子：Ia抗原的诱导、功能特性及作用

J Immunol. 1980 Jun;124(6):2930-5.

5

Allospecific human T cell lines and clones which mediate HLA-DR restricted helper activity.

J Immunol. 1982 Dec;129(6):2451-7.

6

Suppression of T cell responses through competition for T cell growth factor (interleukin 2).通过竞争T细胞生长因子（白细胞介素2）来抑制T细胞反应。

Eur J Immunol. 1982 Mar;12(3):247-9. doi: 10.1002/eji.1830120315.

7

Functionally restricted, allospecific, human helper T cell lines that amplify either B cell or cytolytic T cell responses.功能受限的、同种特异性的人类辅助性T细胞系，可增强B细胞或细胞毒性T细胞反应。

J Exp Med. 1983 May 1;157(5):1675-80. doi: 10.1084/jem.157.5.1675.

8

Human T cell lines with antigen specificity and helper activity.具有抗原特异性和辅助活性的人T细胞系。

Eur J Immunol. 1982 Jun;12(6):468-74. doi: 10.1002/eji.1830120604.

9

A human helper T cell clone secreting both killer helper factor(s) and T cell-replacing factor(s).一种分泌杀伤辅助因子和T细胞替代因子的人辅助性T细胞克隆。

J Immunol. 1982 Jul;129(1):46-51.

10

Generation of cytotoxic T lymphocytes in vitro. I. Response of normal and immune mouse spleen cells in mixed leukocyte cultures.体外细胞毒性T淋巴细胞的产生。I. 混合白细胞培养中正常和免疫小鼠脾细胞的反应。

J Exp Med. 1974 Sep 1;140(3):703-17. doi: 10.1084/jem.140.3.703.

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