Ramarli D, Parodi B, Fabbi M, Corte G, Lanzavecchia A
J Exp Med. 1984 Jan 1;159(1):318-23. doi: 10.1084/jem.159.1.318.
Human alloreactive proliferating T cell clones have been compared for their capacity to provide help for B cell activation and the generation of a specific cytotoxic response. The results demonstrate that, when triggered by the relevant alloantigen, the same T cell clone can induce a strong polyclonal B cell activation and serve as the only source of helper cells for the generation of a specific cytotoxic response by any source of CTL precursors against any stimulator cell present in culture.
已对人类同种异体反应性增殖性T细胞克隆进行了比较，以评估它们为B细胞激活提供帮助以及产生特异性细胞毒性反应的能力。结果表明，当受到相关同种异体抗原触发时，同一个T细胞克隆可诱导强烈的多克隆B细胞激活，并作为辅助细胞的唯一来源，使任何来源的CTL前体细胞针对培养中存在的任何刺激细胞产生特异性细胞毒性反应。
